Abstract
Soft bioelectronics, seamlessly interfacing with the human body to enable both recording and modulation of curvilinear biological tissues and organs, have significantly driven fields such as digital healthcare, human-machine interfaces, and robotics. Nonetheless, intractable challenges persist due to the onerous demand for imperceptible, burden-free, and user-centric comfortable bioelectronics. Porous soft bioelectronics is a new way to a library of imperceptible bioelectronic systems, that form natural interfaces with the human body. In this review, we provide an overview of the development and recent advances in multifunctional porous engineered soft bioelectronics, aiming to bridge the gap between living biotic and stiff abiotic systems. We first discuss strategies for fabricating porous, soft, and stretchable bioelectronic materials, emphasizing the concept of materials-level porous engineering for breathable and imperceptible bioelectronics. Next, we summarize wearable bioelectronics devices and multimodal systems with porous configurations designed for on-skin healthcare applications. Moving beneath the skin, we discuss implantable devices and systems enabled by porous bioelectronics with tissue-like compliance. Finally, existing challenges and translational gaps are also proposed to usher further research efforts towards realizing practical and clinical applications of porous bioelectronic systems; thus, revolutionizing conventional healthcare and medical practices and opening up unprecedented opportunities for long-term, imperceptible, non-invasive, and human-centric healthcare networks.