Abstract
Developmental Language Disorder (DLD) is a common neurodevelopmental condition characterized by not only significant difficulty with language learning, comprehension, and expression but also with executive, procedural and/or motor functions. The understanding of the brain abnormalities in DLD remains largely unclear and functional MRI (fMRI) studies have largely focused on the language network. Using resting-state fMRI, we investigated whole-brain functional connectivity (FC) in 22 children with DLD and 23 with typical language development (TD), aged 7-to-13-years. Using a non-parametric network-based statistics approach, we found that children with DLD had an extensive network of lower FC across the whole brain, compared to the TD children. In particular, the sensorimotor (SM), cognitive control (CC) and default-mode (DM) networks included the largest amounts of altered FC. In detail, FC links within the DM network and between the SM and DM networks, and between the SM and CC networks were the most altered. No FC was found to be significantly higher in the children with DLD than in their peers with TD. To our knowledge, this is the first investigation of resting-state FC in children with DLD, showing widespread functional brain abnormalities that are not limited to the language network, but rather involve networks supporting other cognitive and motor functions. Such extensive functional abnormalities offer a potential explanation for the other cognitive and motor impairments characterizing DLD.