An explainable and efficient deep learning framework for EEG-based diagnosis of Alzheimer's disease and frontotemporal dementia

一种基于脑电图诊断阿尔茨海默病和额颞叶痴呆的可解释且高效的深度学习框架

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Abstract

The early and accurate diagnosis of Alzheimer's Disease and Frontotemporal Dementia remains a critical challenge, particularly with traditional machine learning models which often fail to provide transparency in their predictions, reducing user confidence and treatment effectiveness. To address these limitations, this paper introduces an explainable and lightweight deep learning framework comprising temporal convolutional networks and long short-term memory networks that efficiently classifies Frontotemporal dementia (FTD), Alzheimer's Disease (AD), and healthy controls using electroencephalogram (EEG) data. Feature engineering has been conducted using modified Relative Band Power (RBP) analysis, leveraging six EEG frequency bands extracted through power spectrum density (PSD) calculations. The model achieves high classification accuracies of 99.7% for binary tasks and 80.34% for multi-class classification. Furthermore, to enhance the transparency and interpretability of the framework, SHAP (SHapley Additive exPlanations) has been utilized as an explainable artificial intelligence technique that provides insights into feature contributions.

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