Abstract
Salvia divinorum is a psychoactive plant presenting a complex pharmacological profile, attracting significant scientific interest due to its potential therapeutic applications and associated health risks. This review provides a comprehensive analysis of the toxic and therapeutic effects of S. divinorum, evaluating its potential medical applications while highlighting the risks associated with its consumption. Additionally, the review examines the plant's recreational use, global consumption trends, and legal status. By synthesising current research, this article aims to clarify the implications of S. divinorum use and inform future studies on its pharmacological potential and regulatory considerations.