Abstract
BACKGROUND: Cerebral venous thrombosis (CVT) is a rare cerebrovascular disorder that predominantly affects younger individuals. Its development is influenced by multiple factors, including hypercoagulability, hemodynamic abnormalities, and venous vessel wall injury. Thyrotoxicosis is an uncommon but increasingly recognized predisposing factor for CVT. OBSERVATIONS: The authors present the case of a young female with thyrotoxicosis-induced CVT who achieved successful recovery following endovascular intervention and therapeutic plasma exchange (TPE). LESSONS: This report emphasizes the clinical importance of recognizing thyrotoxicosis as a risk factor for CVT, underscores the therapeutic potential of TPE in thyroid storm complicated by thrombosis, and provides clinical reference for endovascular intervention in the treatment of CVT. https://thejns.org/doi/10.3171/CASE25820.