Abstract
BACKGROUND: Poststroke fatigue (PSF) affects nearly 50% of stroke survivors, severely impacting functional recovery and quality of life. Physical activity (PA) interventions show promise in mitigating fatigue, yet evidence remains fragmented across study designs and intervention types. OBJECTIVE: This scoping review aims to systematically map the literature on PA interventions for PSF, identifying key concepts, evidence gaps, and implementation characteristics to guide future research. METHODS: Using a 5-step framework, we will search PubMed, Web of Science, Scopus, Embase, PsycINFO, CINAHL, and the Cochrane Library from the inception of the databases to 2025. Gray literature and trial registries will be included. Two reviewers will independently screen titles, abstracts, and full texts using predefined criteria. Data extraction will focus on intervention components, fatigue assessment tools, and implementation outcomes. RESULTS: Initial searches identified 8268 articles. The study selection process is expected to finish in February 2026, and the manuscript will be submitted in June 2026. CONCLUSIONS: The conduct of this scoping review is expected to synthesize a fragmented evidence base, providing a clear evidence map of PA interventions for PSF. The findings will identify key gaps and inform the design of future definitive studies and evidence-based clinical guidelines, ultimately contributing to improved care for stroke survivors experiencing fatigue. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/80703.