Hemoglobin SC Sickle Cell Disease Presenting as Acute Ischemic Stroke With Moyamoya Syndrome in an Adult: A Case Report

成人镰状细胞病(血红蛋白SC)表现为急性缺血性卒中伴烟雾病:病例报告

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Abstract

Moyamoya disease is a rare condition where blood vessels at the base of the brain become narrow or blocked. This leads to the growth of small, fragile vessels that look like a "puff of smoke" on imaging tests like CT or MRI scans. These vascular changes predominantly involve the terminal portion of the internal carotid arteries and the proximal segments of the anterior and middle cerebral arteries, leading to progressive stenosis and the development of collateral networks. Although the exact cause of moyamoya disease is unknown, it increases the risk of having a stroke. In this disease, there is partial or complete occlusion or narrowing in the terminal part of the carotid artery, seen in arterial imaging. When these intracerebral vessel changes happen along with other conditions, such as autoimmune diseases, vasculitis, hematological conditions like sickle cell anemia, renal problems like polycystic kidney disease, renal artery narrowing, and any metabolic causes, it is called moyamoya syndrome (MMS).  Our case report describes how we diagnosed and managed a 26-year-old male from Nigeria with MMS.

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