Abstract
Electrospinning has emerged as a highly effective technique for fabricating micro- and nanofibers, which are characterized by high porosity, large surface area, and structural mimicry of the extracellular matrix (ECM). These properties render it particularly suitable for biomedical applications. This review provides a comprehensive overview of recent developments in electrospinning-based strategies across various biomedical fields, including tissue engineering, drug delivery, wound healing, enzyme immobilization, biosensing, and protective materials. The distinctive advantages of electrospun fibers-such as excellent biocompatibility, tunable architecture, and facile surface functionalization-are discussed, alongside challenges such as the toxicity of organic solvents and limitations in scalability. Emerging approaches, including environmentally benign electrospinning techniques and integration with advanced technologies such as 3D printing and microfluidics, present promising solutions for intelligent and personalized biomedical applications.