Abstract
BACKGROUND: Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population. METHODS: The research analyzed specific genetic variations-TNF-α -308 G/A, TNF-α -857 C/T, TNF-α -238G/A, IL1B-3953 C/T, and IL1RN -2018T/C SNPs-within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes. RESULTS: Findings revealed a significant association between the IL1B-3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053-5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α -857 C/T SNP among migraine patients. CONCLUSION: Overall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B-3953 C/T SNP as a potential biomarker for migraine susceptibility.