Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

单细胞转录组学揭示人脑中特定的RNA编辑特征

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Abstract

While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.

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