Abstract
Background/Objectives: To systematically evaluate scientific evidence related to the influence of psychological stress on the response to periodontal treatment. Methods: PubMed/NCBI (National Center for Biotechnology Information, US National Library of Medicine), Web of Science (ClarivateTM), EBSCOHost, SCOPUS, and ProQuest databases were searched for published clinical studies in English up to May 2024. The quality of each study was assessed using the Ottawa-Newcastle scale. Results: Of 803 relevant articles identified, 8 were included in the qualitative synthesis qualitative synthesis. These studies involved 445 patients who completed the follow-up period, ranging from 6 weeks to 6 months. Stressed patients were more likely to experience higher levels of PPD and BOP compared to non-stressed patients. In total, 75% of the included studies showed a positive relationship between stress and response to NSPT, 12.5% observed a negative relationship, and the remaining 12.5% found some degree of relationship in the results of clinical periodontal parameters. The level of evidence is categorized according to the quality of the synthesis presented. Conclusions: There is a positive correlation between psychological stress and periodontal treatment response, indicating that stress may negatively influence the clinical outcomes of NSPT. Stress may reduce the inflammatory response, which is crucial for eliminating periodontal micropathogens after periodontal treatment.