Abstract
Background/Objectives: Overcoming an oncological process has a significant impact on lower-extremity sarcoma survivors' quality of life, due to the deterioration in their physical and functional state. This study evaluated the effects of a six-month multicomponent physical training program on the physical function and quality of life of a mesenchymal chondrosarcoma survivor. Methods: The mesenchymal chondrosarcoma survivor was subjected to an internal hemipelvectomy including right hemipelvis plus femoral joint and resection of the right proximal femur followed by chemotherapy and radiotherapy according to the oncology protocol. The program was performed twice weekly and included resistance, cardiorespiratory, trunk control, and stability exercises. Results: Functional assessments revealed improvements in hand grip strength, walking speed, balance, and coordination. The Timed Up and Go Test showed a 50% reduction in completion time, reflecting better mobility and strength. Additionally, gait speed increased significantly, and balance trials indicated enhanced coordination. Quality of life evaluations indicated progress in physical health, psychological well-being, and environmental engagement. Conclusions: Taken together, this research emphasizes the importance of tailored exercise interventions for sarcoma survivors, particularly those with significant physical impairments. Such programs are vital complements to conventional rehabilitation strategies, fostering physical activity adapted to individual needs. By addressing the multifaceted challenges of survivorship, these interventions enhance functional capacity, reduce disability, and improve overall well-being. Therefore, this case study highlights the program's effectiveness in managing post-treatment sequelae, opening a pathway to improved physical autonomy and quality of life.