Abstract
CONTEXT: Skin is the largest organ in the body. Ideal skin gives a youthful appearance and has an important role in an individual's perception toward life. Acne scars can affect one's confidence and self-esteem. Our clinical study focuses on the reduction of these scars to improve the appearance with additional adjuncts on the skin. This study aims to evaluate the efficacy of intradermal platelet-rich plasma (PRP) with and without vitamin C serum (VCS) using dermaroller (DR) for postacne atrophic scars. AIM: 1. To evaluate the efficacy of intradermal PRP without VCS for postacne atrophic scars. 2. To evaluate the efficacy of IPRP with VCS for postacne atrophic scars. 3. To compare the efficacy of IPRP with and without VCS for postacne atrophic scars. MATERIALS AND METHODS: An in vivo split-face clinical study was conducted on 15 patients divided into two groups, that is, 1(IPRP without VCS) and 2 (IPRP with VCS) over a period of 18 months with a chief complaint of bilateral presentation of postatrophic acne scars attending the Department of Dermatology and the Department of Oral and Maxillofacial Surgery. Convenience sampling technique was used and intraexaminer reliability was done using kappa statistics and single blinding for the observer who was assessing. The study was conducted after approval from institution ethics committee board. STATISTICAL ANALYSIS: There was a statistically nonsignificant difference [P > .05] for GIS and PSS at 7(th) POD between both groups A and B. There was a high statistical difference noted between both the groups A and B [P < .01] for GIS and PSS during the 20(th) POD, with higher mean score for group B when compared to group A. RESULTS: There was a statistically highly significant difference seen for the frequencies of subjects with various scores between both groups (P < .01) with higher no of subjects having lower scores in group 1 while higher no of subjects having higher scores in group 2. There was a statistically significant difference seen for the frequencies of subjects with various scores between both groups (P < .05) with higher no of subjects having lower scores in group 1 while higher no of subjects having higher scores in group 2. Global Improvement Score was compared between 7 days vs 20 days (P < .05), with a higher mean score for 20 days when compared to that for 7 days. Patient Satisfaction Score was compared between 7 days vs 20 days (P < .01), with a higher mean score for 20 days when compared to that for 7 days. Global Improvement Score was compared between 7 days vs 20 days (P < .01), with a higher mean score for 20 days when compared to 7 days. CONCLUSION: The use of DR followed by intradermal PRP with topical VCS application is an excellent combination therapy for the treatment of postacne atrophic scars. These results of combination therapy have shown excellent positive indications in treating postacne atrophic scars and would open potential opportunities for future research.