Abstract
Hepatitis C virus infection remains one of the most critical healthcare issues worldwide, attracting attention for its high chronicity and extrahepatic impact. The continued development of direct antiviral antivirals (DAAs) has made hepatitis C virus infection curable. In recent years, it has been found that dysbiosis is often observed in chronic liver diseases, and chronic hepatitis C (CHC) is one of them. However, the role of intestinal flora and whether DAA has any effect on it remains unclear. In our review, we summarize the changes in intestinal flora before and after DAA treatment in different stages of CHC, as well as the research progress of probiotics in recent years, to provide new thinking for further research on the interrelationship between intestinal flora and CHC as well as for the clinical treatment of CHC.