Abstract
BACKGROUND: Liver cancer poses a major health burden worldwide. Therefore, surgical resection is an important treatment option for patients with liver cancer. In situs inversus totalis (SIT), a rare genetic condition, organs such as the heart, liver, spleen, and stomach are unpaired in the chest and abdominal cavity and their positions are opposite their usual positions. CASE PRESENTATION: We report a case of SIT with a tumor in the right posterior lobe of the liver in a 70-year-old man. This patient was successfully treated with laparoscopic resection. CONCLUSIONS: This case emphasizes that laparoscopic hepatectomy, comprising comprehensive preoperative preparation and fine intraoperative cooperation, is safe and feasible in patients with SIT.