Integrated widely targeted metabolomics and flavoromics reveal processing-driven dynamic changes in functional metabolites of Eucommia ulmoides leaf tea

整合广泛靶向的代谢组学和风味组学分析揭示了杜仲叶茶加工过程中功能代谢物的动态变化。

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Abstract

This study employed a widely targeted metabolomics approach combined with flavoromics evaluation to systematically analyze dynamic metabolic variations under four processing techniques: fresh EUL (XY), traditionally dried EUL (HG), green tea processed EUL (GT), and black tea processed EUL (BT). A total of 1839 non-volatile metabolites and 289 volatile metabolites were identified. Key affected metabolites included amino acids (e.g., essential amino acids upregulated 90 % in HG), lipids (oxidized fatty acids elevated in BT), phenolic acids (23 % increase in GT), flavonoids (120+ downregulated in BT), nucleotides, and terpenoids. Each processing method demonstrates unique advantages: HG preserves amino acids, GT enhances catechin content, and BT optimizes secondary metabolites. This study provides the first comprehensive metabolic map of EUL processing, offering a scientific foundation for standardizing product quality and developing functional applications.

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