Interleukin-1α Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation

白细胞介素-1α 是人类支气管成纤维细胞对嗜酸性炎症反应的关键介质

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作者:Ksenija Bernau, Jonathan P Leet, Heather Floerke, Ellen M Bruhn, Andrea L Noll, Ivy S McDermott, Stephane Esnault, Nizar N Jarjour, Nathan Sandbo

Conclusions

IL1α appears to be a critical component of the soluble eosinophil-derived milieu that drives pro-inflammatory bronchial fibroblast responses and associates with eosinophilic inflammation following SBP-Ag. Disruption of IL1α-signaling could modify the downstream effects of eosinophilic inflammation on airway remodeling.

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