Abstract
BACKGROUND: The clinical and laboratory characteristics of hidradenitis suppurativa (HS), particularly indicators related to disease severity, remain inadequately explored in Asian populations. OBJECTIVES: To characterize the clinical and laboratory features of HS in Chinese patients and to identify risk factors for disease severity. METHODS: We retrospectively analyzed 197 patients with HS in China. Demographic, clinical, and laboratory data were collected. Disease severity was graded using the Hurley staging system. Comprehensive statistical analyses were conducted. RESULTS: Among 197 patients, 87.8% were male (male-to-female ratio 7.2:1). Females had a shorter diagnostic delay than males (p = 0.011). Obesity was present in 33.0% of HS patients. Metabolic abnormalities included reduced HDL-c (30.0%), elevated blood glucose (29.1%), increased TG (14.93%), TC (10.31%), and LDL-c (8.96%). Neutrophil-related indices (WBC, ANC, NEUT%) and liver function markers (TP, albumin, ALT, AST, TB) were significantly associated with progression to Hurley stage III. ROC analysis showed modest discrimination for these indicators (AUCs, 0.605-0.652). In multivariable logistic regression analysis, TP remained an independent risk factor for progression to Hurley stage III (OR, 1.240; 95% CI, 1.101-1.397; p = 0.010). A multivariable logistic regression model that integrated significant predictors achieved an AUC of 0.689. This indicated moderate discrimination for advanced disease severity. CONCLUSION: Chinese patients with HS exhibited a pronounced male predominance and relatively mild metabolic abnormalities. Neutrophil-related indices and TP, especially when TP was interpreted together with albumin, were associated with progression to Hurley stage III.