α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses

Increased α-synuclein immunoreactivity has been associated with inflammatory activity in multiple sclerosis (MS) lesions, but the function of α-synuclein in neuroinflammation remains unknown. The

Our findings indicate a functional role of α-synuclein in early EAE by increasing Th1 cell-mediated immune response.