BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis

BRAF V600E 与患有朗格汉斯细胞组织细胞增生症的成年人发生第二原发癌的风险较高相关。

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作者：Acosta-Medina,Aldo A,Kemps,Paul G,Zondag,Timo C E,Abeykoon,Jithma P,Forma-Borst,Jelske,Steenwijk,Eline C,Feijen,Elizabeth A M,Teepen,Jop C,Bennani,N Nora,Schram,Susan M,Shah,Mithun V,Davidge-Pitts,Caroline,Koster,Matthew J,Ryu,Jay H,Vassallo,Robert,Tobin,W Oliver,Young,Jason R,Dasari,Surendra,Rech,Karen,Ravindran,Aishwarya,Cleven,Arjen H G,Verdijk,Robert M,van Noesel,Carel J M,Balgobind,Brian V,Bouma,Gerrit Joan,Saeed,Peerooz,Bramer,Jos A M,de Groen,Ruben A L,Vermaat,Joost S P,van de Sande,Michiel A J,Smit,Egbert F,Langerak,Anton W,van Wezel,Tom,Tonino,Sanne H,van den Bos,Cor,van Laar,Jan A M,Go,Ronald S,Goyal,Gaurav,van Halteren,Astrid G S
期刊：Blood影响因子：23.100
时间：2023起止号：2023 Nov 2;142(18):1570-1575
doi：10.1182/blood.2023021212

Abstract

In this retrospective study, BRAF mutation status did not correlate with disease extent or (event-free) survival in 156 adults with Langerhans cell histiocytosis. BRAFV600E was associated with an increased incidence of second malignancies, often comprising hematological cancers, which may be clonally related.

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