Abstract
This study evaluated dose differences to the heart, left anterior descending coronary artery (LADCA), and left main coronary artery (LMCA) between diastolic and systolic heart phases in radiation therapy for left-sided breast cancer using deep inspiration breath-hold (DIBH). Diastolic and systolic doses to the heart, LADCA, and LMCA were analyzed using electrocardiogram-gated cardiac computed tomography images from 15 women. Radiation therapy plans were created for a total dose of 50 Gy in 25 fractions. Parameters assessed included volume, D(mean), D(2%), V(5Gy), V(10Gy), V(20Gy), and V(25Gy) for the heart; D(mean), D(2%), V(5Gy), V(10Gy), and V(20Gy) for the LADCA; and D(mean) and D(2%) for the LMCA. The D(mean) of the heart was 5.10 ± 3.04 Gy and 5.03 ± 3.05 Gy for diastole and systole, respectively (mean ± 1 standard deviation), and D(2%) was 37.44 ± 16.03 Gy and 36.15 ± 16.76 Gy. Statistically significant differences were found in the D(mean). LADCA doses showed no significant differences, possibly due to anatomical variations. The D(mean) of the LMCA was 1.88 ± 0.23 Gy and 2.02 ± 0.28 Gy for diastole and systole, and D(2%) was 2.05 ± 0.28 Gy and 2.21 ± 0.30 Gy, with both parameters being statistically significantly higher during systole. Although small, cardiac-phase-dependent dose variations under DIBH were statistically significant, confirming that current non-ECG-gated DIBH remains adequate for cardiac dose management.