Application of a preclinical 18-gene classifier to patients with locally advanced HNSCC

将临床前18基因分类器应用于局部晚期头颈部鳞状细胞癌患者

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作者：Löck,Steffen,Koi,Lydia,Gurtner,Kristin,Lohaus,Fabian,Kemper,Max,Haim,Dominik,Tinhofer,Inge,Kalinauskaite,Goda,Stuschke,Martin,Fleischmann,Maximilian,Rödel,Claus,Grosu,Anca-Ligia,Debus,Jürgen,Belka,Claus,Combs,Stephanie,Boeke,Simon,Baretton,Gustavo,Baumann,Michael,Krause,Mechthild,Linge,Annett
期刊：Clinical and Translational Radiation Oncology影响因子：2.700
时间：2026起止号：2026 Jan;56:101067
doi：10.1016/j.ctro.2025.101067

Abstract

In a previous preclinical trial on human HNSCC xenografts, 18 genes were predictive for adding cetuximab to fractionated radiotherapy. Here, we apply the corresponding 18-gene classifier to two HNSCC patient cohorts treated with combined radiochemotherapy (without cetuximab). We show that the classifier is related to EGFR expression and stratifies patients for loco-regional control (LRC) in both cohorts.

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