Abstract
BACKGROUND: High-precision radiotherapy, especially intensity-modulated radiotherapy (IMRT), requires stringent quality assurance (QA) owing to its complexity. Moreover, patient-specific QA (PSQA) is essential to ensure accurate dose delivery. PURPOSE: This study aimed to develop a centralized PSQA database and analytical environment to improve consistency, efficiency, and safety in QA processes across institutions. METHODS: A relational database was implemented using MOSAIQ Oncology Analytics, integrating structured input forms, statistical process control, and visualization tools. PSQA data from four institutions were collected and analyzed based on AAPM TG-218. RESULTS: A total of 835 PSQA cases were analyzed across five disease sites. Statistically derived action and tolerance limits revealed interfacility variability. Visualization dashboards enabled detection of trends and outliers, supporting real-time QA monitoring. CONCLUSIONS: The system enhanced QA consistency, enabled benchmarking, and supported data-driven improvements. Centralized QA databases are effective tools for advancing radiotherapy quality and safety.