Abstract
OBJECTIVE: The present study aimed to estimate the levels of phosphodiesterase (PDE), myeloperoxidase (MPO) and iron levels in patients with oral cancer. METHOD: 50 patients reporting to the Department of Oral Medicine and Radiology A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore were recruited for the study after taking informed consent. The study group consists of 50 control groups with no complications and 50 oral cancer patients. A 5 ml venous Blood sample was taken, centrifuged and serum was collected for subsequent analysis. 50 normal control samples were also collected for comparison purposes. PDE, MPO and iron levels were estimated. RESULTS: PDE levels were significantly elevated in the case group compared to the control. MPO and iron levels were significantly reduced in the case group compared to the control. CONCLUSION: Immunological and biochemical assessment of oral precancer and cancer patients may help in earlier diagnosis and/or prognosis of these lesions. This may also serve in predicting the malignant potential of the pre-malignant lesions.