Abstract
Hypercarbic respiratory failure due to chronic lung disease is common and presents significant challenges, especially as many patients have multiple comorbidities. Chronic obstructive pulmonary disease (COPD) is one of the leading causes. Patients with COPD and respiratory failure, whether acute or chronic, face worse prognoses. Managing exacerbations of chronic obstructive pulmonary disease (COPD) requires a personalized approach, taking into account the patient's specific clinical profile and comorbid conditions. High-flow nasal cannula (HFNC) therapy has been shown to prevent the need for intubation and may aid in the early extubation process. In patients with COPD who develop hypercapnic respiratory failure while in the intensive care unit (ICU), the decision between high-flow nasal oxygen (HFNO), noninvasive ventilation (NIV), and invasive mechanical ventilation should be made based on the severity of respiratory failure, the patient's overall health status, and individual characteristics. The selection of the appropriate ventilatory support method must also consider factors such as the degree of respiratory distress, blood gas abnormalities, and the presence of other underlying medical conditions that could influence the response to treatment. Each intervention has its indications, benefits, and limitations, and the optimal choice should be tailored to the patient's needs. Noninvasive ventilation (NIMV) has become this population's primary respiratory support method, though comfort issues can hamper patient compliance. High-flow nasal oxygen (HFNO) devices have emerged as a valuable alternative. This study presents cases illustrating the application of conventional NIMV, HFNO, and invasive ventilation in treating hypercarbic respiratory failure. Written consent was obtained from the patient's relatives for all procedures to be performed on all three patients after admission to the intensive care unit.