Abstract
OBJECTIVE: To investigate the efficacy of noninvasive ventilator usage for type II respiratory failure in patients with severe chronic obstructive pulmonary disease (COPD). METHODS: A total of 124 patients with COPD complicated with type II respiratory failure were divided into an observation group (n = 63) and a control group (n = 61) according to their intervention protocols. The patients in the observation group received noninvasive ventilator intervention, and the patients in the control group received bronchodilators, cough suppressants, oxygen therapy, anti-infection medications, nutritional support, and correction of electrolyte imbalances. Lung function indexes, arterial blood gas index, and inflammatory indicators were collected to assess the efficacy of noninvasive ventilator treatment in patients with severe COPD and type II respiratory failure. RESULTS: The levels of FEV(1), FEV(1)/FVC and FEV(1)% of the two groups after treatment were significantly higher than those before treatment (P<0.05), with significantly higher levels in the observation group than the control group (all P<0.05). Post-treatment levels of PaCO(2) decreased significantly while the post-treatment levels of PaO(2) increased significantly (all P<0.05). Additionally, the levels of WBC, CRP and PCT of the control group was significantly higher than that of the observation group after treatment (all P<0.05). CONCLUSION: Noninvasive ventilator treatment can improve hypoxemia, improve lung function and reduce inflammatory responses in patients with COPD complicated with type II respiratory failure, suggesting its potential for wider clinical application.