Abstract
OBJECTIVE: In this study, we investigated the effect of various oxygen therapy regimens on oxygenation in patients with acute type A aortic dissection (AAD). METHODS: A quasi-randomized controlled trial was conducted, in which patients with AAD hospitalized for surgery from June to September 2021 were assigned to the control group (patients received conventional oxygen therapy after postoperative mechanical ventilation, weaning, and extubation) and those who were admitted from October to December 2021 were assigned to the observation group [patients underwent optimally adjusted therapy based on the treatment of the control group, which mainly included prioritized elevation of positive end-expiratory pressure (PEEP) and restricted use of the fraction of inspired oxygen (FiO(2))].The postoperative oxygenation index, blood gas analysis, and duration of mechanical ventilation were compared between the two groups. RESULTS: There were significant differences in oxygenation observed at 2 h postoperatively between the groups. 12, 24, and 72 h postoperatively, the oxygenation index varied significantly between the two groups. There were statistically significant differences in the time effects of the oxygenation index and PaO(2) between the two groups, as well as significant differences in the length of stay in the intensive care unit. CONCLUSION: For the postoperative care of patients with AAD, it is suggested that the minimum FiO(2) required for oxygenation of patients be maintained. In addition, it is possible to enhance PEEP as a priority when PaO(2) is low.