Abstract
Empirical antibiotic treatment is common in acute conjunctivitis despite most cases being non-infectious or viral infections. Operational research (OR) at an eye hospital in Ghana (January-December 2021) identified appropriate antibiotic prescription in 71% of cases. Research dissemination and the sensitisation of key stakeholders followed, including communication of findings and implications to hospital prescribers. We conducted this OR covering January-December 2024 to test the hypothesis that the appropriateness of antibiotic prescriptions will improve, and to investigate the types of antibiotics prescribed and their AWaRe classification. There were 220 acute conjunctivitis cases in 2024, comparable to 2021 (201 cases). Antibiotics were prescribed in 67% of cases in 2024 and 55% in 2021 (aOR 2.51, 95% CI: 1.51-4.19, p < 0.001). Antibiotic prescription appropriateness was higher in 2024 than in 2021: 87% and 71%, respectively (95% CI for change: 5.99-25.99%, p = 0.001). In 2021, only ACCESS and WATCH antibiotics were prescribed. However, 15% of prescriptions in 2024 were RESERVE antibiotics, and multiple antibiotic prescriptions increased from 10% to 22%. This research demonstrates that regular operational research and interventions have the potential to improve antibiotic prescribing in ophthalmic practice in Ghana. It is imperative that the recommendations made by the initial researchers are fully implemented to protect the efficacy of available antibiotics.