Abstract
Plastamination, the pervasive integration of microplastics and nanoplastics into ecological and biological systems, represents a growing yet underrecognized environmental health crisis. This editorial explores the systemic consequences of plastic particle exposure on human health, including neurotoxicity, mitochondrial dysfunction, and gut microbiota disruption, alongside its ecological impacts on soil fertility, food security, and climate change. Drawing on the One Health and planetary health frameworks, the piece calls for urgent regulatory, scientific, and policy interventions to mitigate plastamination's far-reaching risks and ensure intergenerational environmental justice.