Abstract
OBJECTIVE: To investigate the effects of auricular pressure bean combined with wrist-ankle needle on cognitive function and prognosis in migraine patients with comorbid anxiety and depressive disorders. METHODS: A retrospective study was conducted on 99 migraine patients treated at Hefei First People's Hospital between January and December 2023. Based on therapeutic protocols, participants were allocated into auricular pressure bean group (n=22), wrist-ankle needle group (n=20), and combined group (combined auricular pressure bean with wrist-ankle needle, n=57). Pain intensity, depression severity, anxiety severity, cognitive function, and quality of life across three groups were compared before treatment and at 4 weeks post-treatment. Patient migraine recurrence after 3 months was recorded. Pearson correlation analysis was employed to assess the correlation between improvement in anxiety and depression scores and improvement in cognitive function scores. RESULTS: After treatment, all three groups showed a decreasing trend in Visual Analogue Scale, Hamilton Rating Scale for Depression-17 and Hamilton Anxiety Rating Scale scores (all P<0.05). The combined therapy group had lower scores than other groups (all P<0.05). Montreal Cognitive Assessment and Migraine-Specific Quality of Life Questionnaire scores were increased across all groups, with the combined therapy group scoring the highest (all P<0.05). Statistically significant differences existed in recurrence rates among the three groups (P<0.05). Improvements in anxiety and depression symptoms were positively correlated with cognitive function improvements across all treatment modalities (P<0.05). CONCLUSION: The combined therapy can significantly relieve the pain and anxiety and depression symptoms of migraine patients, improve cognitive function and quality of life, and reduce recurrence rate. It shows better efficacy than single therapy.