Abstract
ADAPT is a nationwide initiative to transform cancer care by detecting and responding to tumor evolution in real time. Integrating multimodal data, interpretable AI, and an evolutionary clinical trial platform, ADAPT predicts emerging resistance traits and guides treatment adjustments as tumors change. A unified national infrastructure enables continuous learning across patients, linking discovery directly to care. By making therapy responsive to tumor changes, ADAPT delivers a scalable model designed to improve outcomes in precision oncology.