Abstract
We consider the problem of weakly supervised segmentation on chest radiographs. The chest radiograph is the most common means of screening and diagnosing thoracic diseases. Weakly supervised deep learning models have gained increasing popularity in medical image segmentation. However, these models are not suitable for the critical characteristics presented in chest radiographs: the global symmetry of chest radiographs and dependencies between lesions and their positions. These models extract global features from the whole image to make the image-level decision. The global symmetry can lead these models to misclassification of symmetrical positions of the lesions. Thoracic diseases often have special disease prone areas in chest radiographs. There is a relationship between the lesions and their positions. In this study, we propose a weakly supervised model, called Chest L-Transformer, to take these characteristics into account. Chest L-Transformer classifies an image based on local features to avoid the misclassification caused by the global symmetry. Moreover, associated with Transformer attention mechanism, Chest L-Transformer models the dependencies between the lesions and their positions and pays more attention to the disease prone areas. Chest L-Transformer is only trained with image-level annotations for lesion segmentation. Thus, Log-Sum-Exp voting and its variant are proposed to unify the pixel-level prediction with the image-level prediction. We demonstrate a significant segmentation performance improvement over the current state-of-the-art while achieving competitive classification performance.