Abstract
BACKGROUND: Ultra low dose chest computed tomography (CT) acquisitions have been used for selected emergency room patients with acute dyspnea or minor thoracic trauma. The purpose of this study was to evaluate the diagnostic performance of ultra-low-dose (ULD) chest CT for detecting viral pneumonia patterns compared to standard (STD) dose chest CT. METHODS: All consecutive adult patients with two non-enhanced chest CT acquisitions, one STD and one ULD, for suspicion of viral pneumonia between March 5(th) and April 2(nd) 2020 were included. CT results were divided into two groups: non-viral pneumonia CT or compatible with viral pneumonia CT based on viral pneumonia CT patterns: ground-glass opacity (GGO), consolidation, crazy paving, air bronchogram signs and fibrous stripes. The diagnostic performance of ULD CT for suspicion of viral pneumonia was evaluated. For CTs compatible with viral pneumonia, CT pattern detection on ULD CT was assessed and STD CT was used as a reference. RESULTS: The study included 380 patients with 97 CTs (25.5%) compatible with viral pneumonia. The mean effective doses (EDs) were 1.66 (1.29; 2.18) mSv for STD and 0.20 (0.18; 0.22) mSv for ULD CT (P<0.001). The sensitivity and specificity of ULD CT for viral pneumonia detection were 98.9% and 99.0%, respectively. GGO, consolidation and fibrous stripes were equally visible in STD and ULD in 100% (n=97), 36% (n=35) and 23% (n=22) of compatible viral pneumonia-CT patients, respectively. Air bronchogram sign detection was equivalent, concerning 23% (n=22) of patients in STD and 22% (n=21) in ULD. Crazy paving was visible in 24% (n=23) of patients in STD and only 8% (n=8) in ULD (P=0.003). CONCLUSIONS: In comparison to STD dose chest CT, ULD chest CT, with a mean reduction dose of 88.0%, has comparable diagnostic performance for detecting viral pneumonia on CT.