Use of Degludec in Youth With Type 1 Diabetes and Recurrent Diabetic Ketoacidosis

德谷胰岛素用于治疗1型糖尿病合并复发性糖尿病酮症酸中毒的青少年

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Abstract

This article describes a pediatric diabetes center quality improvement initiative to switch youth with type 1 diabetes and diabetic ketoacidosis (DKA) from insulin glargine to longer-duration insulin degludec to determine whether this change would reduce DKA recurrence. Overall, the change in DKA recurrence with degludec was not statistically significant. However, subgroup analysis showed that race/ethnicity and insurance status were significantly associated with change in DKA rates. The association of degludec and decreased rates of repeat DKA in Hispanics and privately insured individuals requires further exploration.

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