Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies

发育生物学中的波与模式:以脊椎动物体节形成和羽芽形成为例

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Abstract

In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns. We base our discussion around two well known patterning events that take place in the early embryo: somitogenesis and feather bud formation. We outline mathematical models to describe each patterning mechanism, present the results of numerical simulations and discuss the validity of each model in relation to our example patterning processes.

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