Abstract
White blood cells (WBCs) in the human immune system defend against infection and protect the body from external hazardous objects. They are comprised of neutrophils, eosinophils, basophils, monocytes, and lymphocytes, whereby each accounts for a distinct percentage and performs specific functions. Traditionally, the clinical laboratory procedure for quantifying the specific types of white blood cells is an integral part of a complete blood count (CBC) test, which aids in monitoring the health of people. With the advancements in deep learning, blood film images can be classified in less time and with high accuracy using various algorithms. This paper exploits a number of state-of-the-art deep learning models and their variations based on CNN architecture. A comparative study on model performance based on accuracy, F1-score, recall, precision, number of parameters, and time was conducted, and DenseNet161 was found to demonstrate a superior performance among its counterparts. In addition, advanced optimization techniques such as normalization, mixed-up augmentation, and label smoothing were also employed on DenseNet to further refine its performance.