Abstract
The current article describes a process to mitigate challenges that arise when medical practitioners and data specialists operate with differing terminologies and face technological and organizational barriers in accessing and utilizing medical big data. We present a structured methodology for improving access to clinical data and apply this approach using a case study focused on optimizing antibiotic management for patients with gram-negative bloodstream infections. Using the ArchiMate® organizational architecture language, we developed a project framework that aligns strategic, business, application, and technological layers of hospital operations. Each component was used to articulate project goals, guide the implementation process, and track intervention outcomes. After implementing a real-time monitoring tool and engaging clinicians directly in the data workflow, 65% of the identified patients received targeted interventions, and the median duration of antibiotic therapy was reduced from 6 to 5 days. Our approach enabled faster decision-making, and drove meaningful organizational change - demonstrating how structured data access can lead to improved healthcare delivery and patient outcomes.