Abstract
BACKGROUND: Depression, including Bipolar and Unipolar types, is a widespread mental health issue. Conventional diagnostic methods rely on subjective assessments, leading to possible underreporting and bias. Machine learning (ML) and deep learning (DL) offer automated approaches to detect depression using behavioral and demographic data. METHODS: This study proposes a hybrid AI framework combining structured demographic features with synthetic actigraph time-series data. Demographic data is modeled using an XGBoost ensemble, while temporal data is analyzed through a deep convolutional neural network (CNN). The training pipeline includes stratified k-fold cross-validation, hyperparameter tuning, and statistical testing. Model explainability is enhanced using SHAP (XGBoost) and Grad-CAM (CNN). RESULTS: The hybrid model demonstrated strong classification performance across metrics like accuracy, sensitivity, and specificity. Integrating temporal and static features improved prediction of Bipolar and Unipolar Depression. Interpretability tools revealed key features and time patterns influencing predictions. CONCLUSIONS: This work introduces a robust and interpretable framework for depression classification using synthetic multimodal data. While not clinically validated, the model serves as a methodological foundation for future research with real-world datasets.