Abstract
Mycoplasmas are unique prokaryotic pathogens distinguished by their lack of a cell wall. These microorganisms are widespread in nature and can cause severe infections, leading to substantial tissue damage. Recent advances in mycoplasmology, driven by developments in molecular biology and proteomics, have provided novel insights into their pathogenicity and pathogenic mechanisms. However, critical knowledge gaps remain in understanding their biology. Emerging evidence highlights the crucial role of protein post-translational modifications (PTMs) in regulating mycoplasma physiology, including virulence, metabolic adaptation, and persistence. Investigating mycoplasma PTMs in greater depth promises to expand our understanding of their pathogenic strategies and may reveal new targets for therapeutic intervention against mycoplasma-associated diseases.