Suppression of BMP signaling by PHD2 deficiency in Pulmonary Arterial hypertension
肺动脉高压中 PHD2 缺乏导致 BMP 信号传导受到抑制
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作者:Bin Liu, Dan Yi, Jiakai Pan, Jingbo Dai, Maggie M Zhu, You-Yang Zhao, S Paul Oh, Michael B Fallon, Zhiyu Dai
Abstract
BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated BMP signaling in the development of pulmonary arterial hypertension.
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