Abstract
M. Ma, J. Zhao, Q. Wu, K. Xiao, S. Li, H. Zhu, C. Liu, H. Xie, and C. Zuo, "MiRNA-545 Negatively Regulates the Oncogenic Activity of EMS1 in Gastric Cancer," Cancer Medicine 7, no. 6 (2018): 2452-2462, https://doi.org/10.1002/cam4.1520. The above article, published online on 07 May 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Stephen Tait; and John Wiley & Sons Ltd. The retraction has been agreed due to the use of contaminated cell lines in this article. Both the cell lines used to demonstrate the regulatory role of miR-545 in EMS1 expression (SGC-7901 & BGC-823) have been reported to be contaminated with HeLa [1, 2], as has cell line MGC-803 [3, 4]. Thus, the editors consider the conclusions of this article to be invalid. We did not find any evidence of misconduct by the authors. REFERENCES: [1] F. Ye, C. Chen, J. Qin, J. Liu, and C. Zheng, "Genetic Profiling Reveals an Alarming Rate of Cross-Contamination Among Human Cell Lines Used in China," The FASEB Journal 29, no. 10 (2015): 4268-4272, https://doi.org/10.1096/fj.14-266718. [2] X. Bian, Z. Yang, H. Feng, H. Sun, and Y. Liu, "A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell Lines," Scientific Reports 7 (2017): 9774, https://doi.org/10.1038/s41598-017-09660-w. [3] F. Cao, H. Sun, Z. Yang, Y. Bai, X. Hu, Y. Hou, X. Bian, and Y. Liu, "Multiple Approaches Revealed MGc80-3 as a Somatic Hybrid with HeLa Cells Rather than a Gastric Cancer Cell Line," International Journal of Cancer 154, no. 1 (2024): 155-168, https://doi.org/10.1002/ijc.34677. [4] M. Yang, J. He, S. Xia, Y. Wang, J. Xiong, C. Liao, N. Li, S. Qu, and C. Shen, "Investigation of the Mixed Origins of the MGC-803 Cell Line Reveals That It Is a Hybrid Cell Line Derived from HeLa," Human Cell 37 (2024): 560-566, https://doi.org/10.1007/s13577-023-01011-4.