Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
酸性鞘磷脂酶的表达与可切除的胰腺导管腺癌的生存相关
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作者：Gregory C Wilson, Sameer H Patel, Jiang Wang, Kui Xu, Kevin M Turner, Katrin Anne Becker, Alexander Carpinteiro, Ildiko Szabo, Syed A Ahmad, Erich Gulbins
Key messages
Pancreatic ductal adenocarcinoma (PDAC) is a common tumor with poor prognosis. Expression of acid sphingomyelinase (ASM) determines outcome of PDAC. Genetic deficiency or pharmacologic inhibition of ASM promotes tumor growth in a mouse model. Inhibition of ASM during neoadjuvant treatment for PDAC correlates with worse pathology. ASM expression is a prognostic marker and potential target in PDAC.
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