Abstract
BACKGROUND: The impact of different serum uric acid(SUA) concentrations on bone mineral density(BMD) varied across different BMI categories, which might provide useful insights for clinical uric acid-lowering treatments. PURPOSE: To explore whether SUA was associated BMD across BMI categories in men aged ≥ 50 years with type 2 diabetes (T2D). METHODS: The participants were divided into six groups according to SUA levels. Analyses were adjusted for the covariates including weight(Wt), total lean mass(TLM), total fat mass(TFM), total fat ratio(TFr), A/G and a range of other baseline laboratory findings. RESULTS: SUA was associated with total lumbar BMD(TLBMD) (p = 0.013). In the BMI(24-27.999 kg/m(2)) group, SUA was significantly associated with TLBMD (p = 0.02). There was no correlation between SUA and whole-body BMD, as well as femoral neck BMD and total hip BMD. In the BMI < 24 kg/m(2) group, the highest TLBMD value was observed when SUA levels ranged from 420 µmol/L to 479 µmol/L. While BMI:24-27.999 kg/m(2), the highest TLBMD value was showed in the SUA(360-419 μmol/L) group based on adjusted models. The SUA(300-360 μmol/L) group exhibited the highest TLBMD value among the patients with BMI ≥ 28 kg/m(2). CONCLUSION: SUA was correlated with TLBMD in T2D men aged ≥ 50 years. Among patients with BMI 24-27.999 kg/m(2), the SUA concentrations between 360-419 μmol/L might have a protective effect on TLBMD.