Abstract
Herein, we present a case of synovitis, acne, pustular lesions, hyperostosis, and osteitis (SAPHO) syndrome in which the patient had monoclonal gammopathy. To identify whether the patient had blood proliferative disorders, we performed bone marrow aspiration and positron emission tomography-computed tomography (PET-CT) examination. Finally, we diagnosed the patient with SAPHO syndrome and monoclonal gammopathy of undetermined significance (MGUS). The patient was followed up for two years with repeat bone marrow and PET-CT examinations, and no apparent disease progression or progression to another condition was observed. We concluded that SAPHO syndrome may coexist with monoclonal globulinemia; however, the pathogenesis of this combination remains unclear. This phenomenon should be closely monitored by clinicians to avoid misdiagnosis.In patients with SAPHO syndrome who present with MGUS, the diagnostic challenge lies in determining whether the bone pain symptoms are attributable to SAPHO syndrome itself or to the development of bone lesions due to the progression of MGUS to MM. When this rare condition arises, clinicians must exercise careful differentiation, ensuring neither its oversight nor its overdiagnosis as multiple myeloma (MM). CLINICAL TRIAL NUMBER: Not applicable.