Abstract
AIM: To evaluate the effects of exercise training on patients with osteosarcopenic adiposity (OSA). METHODS: A comprehensive search was conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases for randomized controlled trials (RCTs) on exercise treatment for OSA patients. The search included both Chinese and English literature up to April 2024. Reference lists and grey literature were also reviewed. Two researchers independently screened the literature, extracted data, and assessed the quality of included studies. Meta-analysis was performed using RevMan 5.4 software. RESULTS: A total of 7 studies were included in this meta-analysis. Exercise interventions significantly improved bone mineral density (BMD) (MD = 0.0195, 95% CI: 0 to 0.02, P = 0.03), body fat (BF) (MD = -4.0, 95% CI: -5.46 to -2.54, P < 0.01), and hand grip strength (HGS) (MD = 3.13, 95% CI: 0.72 to 5.54, P = 0.01) in patients with OSA. However, no significant differences were observed in skeletal muscle mass index (SMI) (MD = 0.12, 95% CI: -0.26 to 0.50, P = 0.55), gait speed (GS) (SMD = 0.75, 95% CI: -1.26 to 2.76, P = 0.47), or C-reactive protein (CRP) (MD = -0.23, 95% CI: -0.90 to 0.44, P = 0.50). CONCLUSION: Exercise interventions can effectively improve clinical symptoms and signs in OSA patients to varying degrees, highlighting the importance of exercise in the management of OSA.