Abstract
Post-transcriptional modifications encompass a large group of RNA alterations that control gene expression. Methylation of the N(6)-Adenosine (m(6)A) of mRNA is a prevalent modification which alters the life cycle of transcripts. The roles that m(6)A play in regulating cardiac homeostasis and injury response are an active area of investigation, but it is clear that this chemical modification is a critical controller of fibroblast to myofibroblast transition, cardiomyocyte hypertrophy and division, and the structure and function of the extracellular matrix. Here we discuss the latest findings of m(6)A in cardiac muscle and matrix.