Palladium mediated domino reaction: synthesis of isochromenes under aqueous medium

Isochromenes have been synthesized using palladium-catalyzed C-C and C-O bond forming reactions starting from ortho-bromo tertiary benzylic alcohols and internal acetylenes. Notably, this domino process is feasible by using the green solvent, water. The protocol exhibited a broad substrate scope and afforded various isochromenes.