Abstract
We report DGA extraction chromatography isolation of (51)Mn from isotopically enriched (54)Fe. The method has been studied in semi-automated and automated realizations. The former achieves a decay corrected radiochemical yield of 78 ± 1 % (n = 3) and a separation factor of (1.0 ± 0.8) x 10(5) (n = 3). With GE HealthCare's Solid Target Platform (STP) and FASTlab the latter, fully automated method achieves a decay corrected radiochemical yield of 87 ± 1 % (n = 3) and a separation factor of (2.7 ± 0.9) x 10(4) (n = 3). Both setups efficiently isolate cyclotron-produced (51)MnCl(2) suitable for human administration as determined by developed Chemistry, Manufacturing, and Controls (CMC) acceptance criteria, and support exploration of (51)Mn as a clinical diagnostic tool.