Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization

功能性 microRNA 文库筛选确定 hypoxamir miR-24 是平滑肌细胞增殖和血管化的有效调节剂

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作者:Jan Fiedler, Andrea Stöhr, Shashi Kumar Gupta, Dorothee Hartmann, Angelika Holzmann, Annette Just, Arne Hansen, Denise Hilfiker-Kleiner, Thomas Eschenhagen, Thomas Thum

Aims

Here, we asked whether microRNAs (miRNAs, miRs), which are strong posttranscriptional regulators of gene expression, could alter SMC proliferation.

Conclusion

Collectively, we report the identification of the hypoxamir-24 as an inhibitor of SMC proliferation, contributing to loss of vascularization.

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