Abstract
Growing concerns about antibiotic resistance and the pursuit for natural alternatives in animal production have driven the search for dietary additives that promote health and sustainability, without adversely affecting the environment or consumer safety. One such alternative could be Andrographis paniculata (AP), a medicinal plant known for its bioactive compounds with anti-inflammatory, antioxidant, antimicrobial, antiviral and hepatoprotective properties. This review explores the potential of AP supplementation in improving the health and productivity of monogastric livestock, particularly poultry and swine. Key areas of focus include its beneficial effects on the immune and digestive systems, liver function and metabolism, factors that collectively support improved growth performance and production traits. Notably, the review highlights the efficacy of AP supplementation in mitigating the adverse impacts of environmental and physiological stressors such as heat stress, mycotoxin contamination, and microbial infections. Although the current findings underscore the promising potential of AP as a sustainable feed additive, further investigations, particularly in swine, are crucial to fully elucidate its mechanisms of action and broaden its practical applications in animal production systems.